Unknown

Dataset Information

0

Advances and Current Concepts in the Medical Management of Gastroenteropancreatic Neuroendocrine Neoplasms.


ABSTRACT: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare and heterogeneous group of tumors presenting as localised or metastatic disease and in a subset with distinct clinical syndromes. Treatment is aimed at controlling the functional syndrome, eradicating the tumor, and/or preventing further tumor growth. Surgery is the treatment of choice in removing the primary tumor and/or reducing tumor burden but cannot be applied to all patients. Somatostatin analogs (SS-analogs) obtain control of functional syndromes in the majority of GEP-neuroendocrine tumors (NETs); phase III trials have shown that SS-analogs can be used as first-line antiproliferative treatment in patients with slow-growing GEP-NETs. The role of the recently approved serotonin inhibitor, telotristat ethyl, and gastrin receptor antagonist, netazepide, is evolving. Streptozotocin-based chemotherapy has been used for inoperable or progressing pancreatic NENs but the orally administered combination of capecitabine/temozolomide is becoming more popular due to its better tolerability and potential effect in other GEP-NENs. Phase III trials have shown efficacy of molecular targeted therapies in GEP-NETs and of radionuclide treatment in patients with midgut carcinoid tumors expressing somatostatin receptors. Most patients will develop disease progression necessitating further therapeutic options. A combination of currently available treatments along with the molecular signature of each tumor will guide future treatment.

SUBMITTER: Alexandraki KI 

PROVIDER: S-EPMC5733630 | BioStudies | 2017-01-01T00:00:00Z

SECONDARY ACCESSION(S): NCT02651987

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC5611500 | BioStudies
2018-01-01 | S-EPMC5896708 | BioStudies
2016-01-01 | S-EPMC4824717 | BioStudies
2020-01-01 | S-EPMC7512090 | BioStudies
2019-01-01 | S-EPMC6338796 | BioStudies
1000-01-01 | S-EPMC6067804 | BioStudies
1000-01-01 | S-EPMC5542298 | BioStudies
2015-01-01 | S-EPMC4617555 | BioStudies
1000-01-01 | S-EPMC3883302 | BioStudies
2017-01-01 | S-EPMC5726195 | BioStudies