Unknown

Dataset Information

0

Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication.


ABSTRACT: The present study extends an earlier report that retinoic acid (RA) down-regulates IgE Ab synthesis in vitro. Here, we show the suppressive activity of RA on IgE production in vivo and its underlying mechanisms. We found that RA down-regulated IgE class switching recombination (CSR) mainly through RA receptor ? (RAR?). Additionally, RA inhibited histone acetylation of germ-line ? (GL ?) promoter, leading to suppression of IgE CSR. Consistently, serum IgE levels were substantially elevated in vitamin A-deficient (VAD) mice and this was more dramatic in VAD-lecithin:retinol acyltransferase deficient (LRAT-/-) mice. Further, serum mouse mast cell protease-1 (mMCP-1) level was elevated while frequency of intestinal regulatory T cells (Tregs) were diminished in VAD LRAT-/- mice, reflecting that deprivation of RA leads to allergic immune response. Taken together, our results reveal that RA has an IgE-repressive activity in vivo, which may ameliorate IgE-mediated allergic disease.

SUBMITTER: Seo GY 

PROVIDER: S-EPMC5733712 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3820499 | BioStudies
2020-01-01 | S-EPMC7503626 | BioStudies
2012-01-01 | S-EPMC3243786 | BioStudies
1000-01-01 | S-EPMC6074790 | BioStudies
2015-01-01 | S-EPMC4425501 | BioStudies
1000-01-01 | S-EPMC3318743 | BioStudies
1000-01-01 | S-EPMC4879462 | BioStudies
1000-01-01 | S-EPMC5915013 | BioStudies
1000-01-01 | S-EPMC2192876 | BioStudies
2017-01-01 | S-EPMC5591319 | BioStudies