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Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.


ABSTRACT: : Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P?=?0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio?=?4.2, P?=?0.02) compared with 1635GG. In addition, 1635A was associated with 0.4?log10 copies/ml lower median EBV levels in HIV-infected infants (P?=?0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

SUBMITTER: Beima-Sofie K 

PROVIDER: S-EPMC5736409 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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