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Biology of Bone Sarcomas and New Therapeutic Developments.


ABSTRACT: Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.

SUBMITTER: Brown HK 

PROVIDER: S-EPMC5805807 | BioStudies | 2018-01-01

SECONDARY ACCESSION(S): NCT00987636

REPOSITORIES: biostudies

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