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A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.


ABSTRACT: BACKGROUND:Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. OBJECTIVES:To identify genetic contributors to the development of DFUs in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome-wide association study. METHODS:A genome-wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who had ever had a foot ulcer (current or previous) in at least one foot, as well as a positive monofilament test result (i.e. evidence of peripheral neuropathy) recorded in their longitudinal e-health records. A control was defined as an individual with diabetes (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot but who had a positive monofilament test result recorded in either foot in their longitudinal e-health records. RESULTS:There were 699 DFU cases and 2695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The single-nucleotide polymorphism rs80028505 (Chr6p21·31) in MAPK14 reached genome-wide significance with a lowest P-value of 2·45 × 10-8 . The narrow-sense heritability of this phenotype is 0·06. CONCLUSIONS:We suggest that MAPK14 is associated with DFUs.

SUBMITTER: Meng W 

PROVIDER: S-EPMC5829525 | BioStudies | 2017-01-01

SECONDARY ACCESSION(S): rs699947

REPOSITORIES: biostudies

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