Dataset Information


Progression of MDS-UPDRS Scores Over Five Years in De Novo Parkinson Disease from the Parkinson's Progression Markers Initiative Cohort.

ABSTRACT: Background:The Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UDPRS) is a commonly used tool to measure Parkinson disease (PD) progression. Longitudinal changes in MDS-UPDRS scores in de novo PD have not been established. Objective:Determine progression rates of MDS-UPDRS scores in de novo PD. Methods:362 participants from the Parkinson's Progression Markers Initiative, a multicenter longitudinal cohort study of de novo PD, were included. Longitudinal progression of MDS-UPDRS total and subscale scores were modeled using mixed model regression. Results:MDS-UPDRS scores increased in a linear fashion over five years in de novo PD. MDS-UPDRS total score increased an estimated 4.0 points/year, Part I 0.25 points/year, Part II 1.0 points/year, and Part III 2.4 points/year. Conclusions:The expected average progression of MDS-UPDRS scores in de novo PD from this study can assist in clinical monitoring and provide comparative data for detection of disease modification in treatment trials.


PROVIDER: S-EPMC5898442 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5732865 | BioStudies
2019-01-01 | S-EPMC6647468 | BioStudies
1000-01-01 | S-EPMC6001458 | BioStudies
2019-01-01 | S-EPMC6851993 | BioStudies
1000-01-01 | S-EPMC6174385 | BioStudies
2020-01-01 | S-EPMC7197319 | BioStudies
2019-01-01 | S-EPMC6832465 | BioStudies
2017-01-01 | S-EPMC5664303 | BioStudies
2019-01-01 | S-EPMC7098385 | BioStudies
2014-01-01 | S-EPMC4011463 | BioStudies