Unknown

Dataset Information

0

Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer.


ABSTRACT: In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1.02-2.55, P = 0.042; I2 = 10.1%, P = 0.292; n = 99), low miR-145 expression (HR = 1.70, 95% CI: 1.29-2.24, P < 0.001; I2 = 0%, P = 0.560; n = 193) and high miR-196 expression (HR = 0.28, 95% CI: 0.15-0.52, P < 0.001; I2 = 0%, P = 0.950, n = 197). This makes microRNAs such as miR-125, miR-145 and miR-196 potential prognostic biomarkers in cervical cancer.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5908312 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4954718 | BioStudies
2018-01-01 | S-EPMC6174793 | BioStudies
2015-01-01 | S-EPMC4508815 | BioStudies
2019-01-01 | S-EPMC6608935 | BioStudies
1000-01-01 | S-EPMC5386740 | BioStudies
1000-01-01 | S-EPMC6133642 | BioStudies
2016-01-01 | S-EPMC5033452 | BioStudies
2020-01-01 | S-EPMC7261381 | BioStudies
1000-01-01 | S-EPMC4232634 | BioStudies
2020-01-01 | S-EPMC7396529 | BioStudies