ObjectiveTo evaluate on a large scale, across 272 common types of laboratory tests, the impact of healthcare processes on the predictive value of electronic health record (EHR) data.
DesignRetrospective observational study.
SettingTwo large hospitals in Boston, Massachusetts, with inpatient, emergency, and ambulatory care.
ParticipantsAll 669?452 patients treated at the two hospitals over one year between 2005 and 2006.
Main outcome measuresThe relative predictive accuracy of each laboratory test for three year survival, using the time of the day, day of the week, and ordering frequency of the test, compared to the value of the test result.
ResultsThe presence of a laboratory test order, regardless of any other information about the test result, has a significant association (P<0.001) with the odds of survival in 233 of 272 (86%) tests. Data about the timing of when laboratory tests were ordered were more accurate than the test results in predicting survival in 118 of 174 tests (68%).
ConclusionsHealthcare processes must be addressed and accounted for in analysis of observational health data. Without careful consideration to context, EHR data are unsuitable for many research questions. However, if explicitly modeled, the same processes that make EHR data complex can be leveraged to gain insight into patients' state of health.