Dataset Information


MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors.

ABSTRACT: Abnormalities in limbic neural circuits have been implicated in the onset of anxiety disorders. However, the molecular pathogenesis underlying anxiety disorders remains poorly elucidated. Here, we demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) regulates amygdala circuitry to control the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as induces anxiety-like behaviors in mice. MARCKSL1 expression was predominantly localized in the prefrontal cortex (PFC), hypothalamus, hippocampus, and amygdala of the adult mouse brain. MARCKSL1 transgenic (Tg) mice exhibited anxiety-like behaviors dependent on corticotropin-releasing hormone. MARCKSL1 increased spine formation in the central amygdala, and downregulation of MARCKSL1 in the amygdala normalized both increased HPA axis activity and elevated anxiety-like behaviors in Tg mice. Furthermore, MARCKSL1 expression was increased in the PFC and amygdala in a brain injury model associated with anxiety-like behaviors. Our findings suggest that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.


PROVIDER: S-EPMC5952351 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2012-01-01 | S-EPMC3509229 | BioStudies
2017-01-01 | S-EPMC5685810 | BioStudies
2012-01-01 | S-EPMC3164918 | BioStudies
2017-01-01 | S-EPMC5578197 | BioStudies
1000-01-01 | S-EPMC6303682 | BioStudies
2008-01-01 | S-EPMC2601562 | BioStudies
2009-01-01 | S-EPMC2852579 | BioStudies
2017-01-01 | S-EPMC5272817 | BioStudies
2020-01-01 | S-EPMC7039154 | BioStudies
2015-01-01 | S-EPMC4642655 | BioStudies