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Factors Influencing Time-to-diagnosis of Biliary Atresia.


ABSTRACT: OBJECTIVES:Diagnosing biliary atresia (BA) quickly is critical, because earlier treatment correlates with delayed or reduced need for liver transplantation. However, diagnosing BA quickly is also difficult, with infants usually treated after 60 days of life. In this study, we aim to accelerate BA diagnosis and treatment, by better understanding factors influencing the diagnostic timeline. METHODS:Infants born between 2007 and 2014 and diagnosed with BA at our institution were included (n?=?65). Two periods were examined retrospectively: P1, the time from birth to specialist referral, and P2, the time from specialist referral to treatment. How sociodemographic factors associate with P1 and P2 were analyzed with Kaplan-Meier curves and Cox proportional hazard models. In addition, to better characterize P2, laboratory results and early tissue histology were studied. RESULTS:P1 associated with race/ethnicity, with shorter times in non-Hispanic white infants compared to non-Hispanic black and Hispanic infants (P?=?0.007 and P?=?0.004, respectively). P2 associated with referral age, with shorter times in infants referred after 30, 45, or 60 days of life (P?

PROVIDER: S-EPMC5963977 | BioStudies |

REPOSITORIES: biostudies

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