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Genomic analysis of bifunctional Class C-Class D ?-lactamases in environmental bacteria.


ABSTRACT: ?-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to ?-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two ?-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against ?-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional ?-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional ?-lactamases are widespread in nature; these findings also raise concern that bifunctional ?-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.

SUBMITTER: Silveira MC 

PROVIDER: S-EPMC5967600 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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