Dataset Information


Genomic analysis of bifunctional Class C-Class D ?-lactamases in environmental bacteria.

ABSTRACT: ?-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to ?-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two ?-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against ?-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional ?-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional ?-lactamases are widespread in nature; these findings also raise concern that bifunctional ?-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.


PROVIDER: S-EPMC5967600 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4684797 | BioStudies
2007-01-01 | S-EPMC1932750 | BioStudies
2013-01-01 | S-EPMC4018812 | BioStudies
2014-01-01 | S-EPMC4790369 | BioStudies
2019-01-01 | S-EPMC6723624 | BioStudies
2019-01-01 | S-EPMC6963673 | BioStudies
2014-01-01 | S-EPMC3910802 | BioStudies
2010-01-01 | S-EPMC2798486 | BioStudies
2018-01-01 | S-EPMC6121496 | BioStudies
2018-01-01 | S-EPMC6153792 | BioStudies