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Avian Leukosis Virus Subgroup J Attenuates Type I Interferon Production Through Blocking I?B Phosphorylation.


ABSTRACT: Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and enhances susceptibility to secondary infection, resulting in great economic losses. Although ALV-J-induced immunosuppression has been well established, the underlying molecular mechanism for such induction is still unclear. Here, we report that the inhibitory effect of ALV-J infection on type I interferon expression is associated with the down-regulation of transcriptional regulator NF-?B in host cells. We found that ALV-J possess the inhibitory effect on type I interferon production in HD11 cells and that ALV-J causes the up-regulation of I?B? and down-regulation of NF-?B p65, and that ALV-J blocks the phosphorylation of I?B? on Ser32/36 amino acid residues. Collectively, our findings provide insights into the pathogenesis of ALV-J.

SUBMITTER: Lin W 

PROVIDER: S-EPMC5980975 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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