Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis.
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ABSTRACT: The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.
SUBMITTER: Liu D
PROVIDER: S-EPMC6009197 | BioStudies | 2018-01-01T00:00:00Z
REPOSITORIES: biostudies
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