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Skeletal vascular perfusion is altered in chronic kidney disease.


ABSTRACT: Patients with chronic kidney disease (CKD) are at an alarming risk of cardiovascular disease and fracture-associated mortality. CKD has been shown to have negative effects on vascular reactivity and organ perfusion. Although alterations in bone blood flow are linked to dysregulation of bone remodeling and mass in multiple conditions, changes to skeletal perfusion in the setting of CKD have not been explored. The goal of this study was to establish the effect of CKD on skeletal perfusion in a rat model of CKD. In two experiments with endpoints at 30 and 35?weeks of age, respectively, normal (NL) and Cy/+ (CKD) animals (n?=?6/group) underwent in vivo intra-cardiac fluorescent microsphere injection to assess bone tissue perfusion. These two separate time points aimed to describe skeletal perfusion at 30 and 35?weeks based on previous studies demonstrating significant progression of hyperparthyroid bone disease during this timeframe. CKD animals had blood urea nitrogen (BUN) levels significantly higher than NL at both 30 and 35?weeks. At 30?weeks, perfusion was significantly higher in the femoral cortex (+259%, p?

SUBMITTER: Aref MW 

PROVIDER: S-EPMC6020396 | BioStudies | 2018-01-01T00:00:00Z

REPOSITORIES: biostudies

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