Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA397781GSE102456PRJNA397776PRJNA397778
SUBMITTER: Jensen CT
PROVIDER: S-EPMC6028518 | BioStudies | 2018-01-01
SECONDARY ACCESSION(S): 10.15252/embj.201797105
REPOSITORIES: biostudies
Alberti-Servera Llucia L von Muenchow Lilly L Tsapogas Panagiotis P Capoferri Giuseppina G Eschbach Katja K Beisel Christian C Ceredig Rhodri R Ivanek Robert R Rolink Antonius A
The EMBO journal 20171013 24
Single-cell RNA sequencing is a powerful technology for assessing heterogeneity within defined cell populations. Here, we describe the heterogeneity of a B220+CD117intCD19-NK1.1- uncommitted hematopoietic progenitor having combined lymphoid and myeloid potential. Phenotypic and functional assays revealed four subpopulations within the progenitor with distinct lineage developmental potentials. Among them, the Ly6D+SiglecH-CD11c- fraction was lymphoid-restricted exhibiting strong B-cell potential, ...[more]