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Brain function characteristics of chronic fatigue syndrome: A task fMRI study.


ABSTRACT: The mechanism underlying neurological dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is yet to be established. This study investigated the temporal complexity of blood oxygenation level dependent (BOLD) changes in response to the Stroop task in CFS patients. 43 CFS patients (47.4?±?11.8?yrs) and 26 normal controls (NCs, 43.4?±?13.9?yrs) were included in this study. Their mental component summary (MCS) and physical component summary (PCS) from the 36-item Short Form Health Survey (SF-36) questionnaire were recorded. Their Stroop colour-word task performance was measured by accuracy and response time (RT). The BOLD changes associated with the Stroop task were evaluated using a 2-level general linear model approach. The temporal complexity of the BOLD responses, a measure of information capacity and thus adaptability to a challenging environment, in each activated region was measured by sample entropy (SampEn). The CFS patients showed significantly longer RTs than the NCs (P?

SUBMITTER: Shan ZY 

PROVIDER: S-EPMC6051500 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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