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Redox-responsive cisplatin nanogels for anticancer drug delivery.


ABSTRACT: Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6057802 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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