Dataset Information


Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation.

ABSTRACT: Management for patients with diabetes experiencing myocardial infarction remains a challenge. Here the authors show that hyperglycemia- and hyperinsulinemia-induced microRNA-24 (miR-24) reduction and O-GlcNAcylation in the diabetic heart contribute to poor survival and increased infarct size in diabetic myocardial ischemia/reperfusion (I/R). In a mouse model of myocardial I/R, pharmacological or genetic overexpression of miR-24 in hearts significantly reduced myocardial infarct size. Experimental validation revealed that miR-24 targets multiple key proteins, including O-GlcNac transferase, ATG4A, and BIM, to coordinately protect the myocardium from I/R injury. These results establish miR-24 as a promising therapeutic candidate for diabetic I/R injury.

PROVIDER: S-EPMC6058960 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC7725936 | BioStudies
| S-EPMC7703924 | BioStudies
| S-EPMC8351495 | BioStudies
| S-EPMC8121980 | BioStudies
| S-EPMC8463091 | BioStudies
| S-EPMC6156366 | BioStudies
| S-EPMC5825060 | BioStudies
| S-EPMC7814404 | BioStudies
| S-EPMC7526458 | BioStudies
| S-EPMC5593976 | BioStudies