Unknown

Dataset Information

0

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.


ABSTRACT: NMDA-type glutamate receptors (NMDARs) are ligand-gated ion channels that mediate excitatory neurotransmission in the CNS. Here we describe functional and single-channel properties of triheteromeric GluN1/GluN2A/GluN2C receptors, which contain two GluN1, one GluN2A, and one GluN2C subunits. This NMDAR has three conductance levels and opens in bursts similar to GluN1/GluN2A receptors but with a single-channel open time and open probability reminiscent of GluN1/GluN2C receptors. The deactivation time course of GluN1/GluN2A/GluN2C receptors is intermediate to GluN1/GluN2A and GluN1/GluN2C receptors and is not dominated by GluN2A or GluN2C. We show that triheteromeric GluN1/GluN2A/GluN2C receptors are the predominant NMDARs in cerebellar granule cells and propose that co-expression of GluN2A and GluN2C in cerebellar granule cells occludes cell surface expression of diheteromeric GluN1/GluN2C receptors. This new insight into neuronal GluN1/GluN2A/GluN2C receptors highlights the complexity of NMDAR signaling in the CNS.

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC6090556 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5924706 | BioStudies
2017-01-01 | S-EPMC5568803 | BioStudies
2018-01-01 | S-EPMC5905667 | BioStudies
2017-01-01 | S-EPMC5391998 | BioStudies
2013-01-01 | S-EPMC3629906 | BioStudies
2014-01-01 | S-EPMC4201136 | BioStudies
2018-01-01 | S-EPMC5878673 | BioStudies
1000-01-01 | S-EPMC6198500 | BioStudies
2014-01-01 | S-EPMC4201086 | BioStudies
2015-01-01 | S-EPMC4864154 | BioStudies