Unknown

Dataset Information

0

Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.


ABSTRACT: The neuropeptides tachykinin2 (Tac2) and kisspeptin (Kiss1) in hypothalamic arcuate nucleus Kiss1 (Kiss1ARH) neurons are essential for pulsatile release of GnRH and reproduction. Since 17?-estradiol (E2) decreases Kiss1 and Tac2 mRNA expression in Kiss1ARH neurons, the role of Kiss1ARH neurons during E2-driven anorexigenic states and their coordination of POMC and NPY/AgRP feeding circuits have been largely ignored. Presently, we show that E2 augmented the excitability of Kiss1ARH neurons by amplifying Cacna1g, Hcn1 and Hcn2 mRNA expression and T-type calcium and h-currents. E2 increased Slc17a6 mRNA expression and glutamatergic synaptic input to arcuate neurons, which excited POMC and inhibited NPY/AgRP neurons via metabotropic receptors. Deleting Slc17a6 in Kiss1 neurons eliminated glutamate release and led to conditioned place preference for sucrose in E2-treated KO female mice. Therefore, the E2-driven increase in Kiss1 neuronal excitability and glutamate neurotransmission may play a key role in governing the motivational drive for palatable food in females.

SUBMITTER: Qiu J 

PROVIDER: S-EPMC6103748 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6179576 | BioStudies
1000-01-01 | S-EPMC2736090 | BioStudies
2016-01-01 | S-EPMC5048571 | BioStudies
2014-01-01 | S-EPMC4183666 | BioStudies
2016-01-01 | S-EPMC4884339 | BioStudies
2018-01-01 | S-EPMC6308029 | BioStudies
1000-01-01 | S-EPMC5034606 | BioStudies
2008-01-01 | S-EPMC2276717 | BioStudies
2013-01-01 | S-EPMC3812230 | BioStudies
2020-01-01 | S-EPMC7159888 | BioStudies