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Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial.


ABSTRACT: INTRODUCTION:More than 90% of amyotrophic lateral sclerosis (ALS) patients have muscle cramps, but evidence-based treatments have not been available. METHODS:A multicenter, double-blind, placebo-controlled crossover trial of mexiletine 150?mg twice daily was conducted in ALS patients requesting treatment of symptomatic muscle cramps. RESULTS:Muscle cramp frequency was reduced in 18 of 20 patients; 13 reductions were attributed to treatment (P?

SUBMITTER: Oskarsson B 

PROVIDER: S-EPMC6126993 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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