Dataset Information


Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.

ABSTRACT: AIM:Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans. RESULTS:CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens. CONCLUSION:Caenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds.


PROVIDER: S-EPMC6161127 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2009-01-01 | S-EPMC2724478 | BioStudies
2019-01-01 | S-EPMC6381107 | BioStudies
2020-01-01 | S-EPMC7564736 | BioStudies
2018-01-01 | S-EPMC6111076 | BioStudies
2016-01-01 | S-EPMC5039358 | BioStudies
2019-01-01 | S-EPMC6499142 | BioStudies
2020-01-01 | S-EPMC7568814 | BioStudies
2014-01-01 | S-EPMC4070918 | BioStudies
2019-01-01 | S-EPMC6700801 | BioStudies
2014-01-01 | S-EPMC4065767 | BioStudies