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STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.


ABSTRACT: OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin response to glucose in type 2 diabetes. PURPOSE:We examined whether obesity and/or type 2 diabetes altered STEAP4 expression in human pancreatic islets. METHODS:Human islets were isolated from deceased donors at two medical centers and processed for quantitative polymerase chain reaction. Organ donors were selected by status as non-diabetic or having type 2 diabetes. Site 1 (Edmonton): N?=?13 type 2 diabetes donors (7M, 6F), N?=?20 non-diabetic donors (7M, 13F). Site 2 (Virginia): N?=?6 type 2 diabetes donors (6F), N?=?6 non-diabetic donors (3M, 3F). RESULTS:STEAP4 showed reduced islet expression with increasing body mass index among all donors (P?

SUBMITTER: Gordon HM 

PROVIDER: S-EPMC6166871 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

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