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Intradermal active full-length DNA A?42 immunization via electroporation leads to high anti-A? antibody levels in wild-type mice.

ABSTRACT: A? immunotherapies with anti-A? antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA A?1-42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased A? levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA A?1-42 immunization delivered via electroporation has potential to be used in the clinical setting.

SUBMITTER: Rosenberg RN 

PROVIDER: S-EPMC6192700 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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