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Persistent mRNA and miRNA expression changes in irradiated baboons.


ABSTRACT: We examined the transcriptome/post-transcriptome for persistent gene expression changes after radiation exposure in a baboon model. Eighteen baboons were irradiated with a whole body equivalent dose of 2.5 or 5?Gy. Blood samples were taken before, 7, 28 and 75-106 days after radiation exposure. Stage I was a whole genome screening for mRNA combined with a qRT-PCR platform for detection of 667 miRNAs. Candidate mRNAs and miRNAs differentially up- or down-regulated in stage I were chosen for validation in stage II using the remaining samples. Only 12 of 32 candidate genes provided analyzable results with two mRNAs showing significant 3-5-fold differences in gene expression over the reference (p?

SUBMITTER: Port M 

PROVIDER: S-EPMC6194144 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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