Dataset Information


Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.

ABSTRACT: Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in host defense is less understood. We report intact AIM2 inflammasome responses in mice lacking type I IFN signaling during infection with F. novicida. Lack of type I IFN signaling conferred protection to F. novicida infection in contrast to the increased susceptibility in AIM2-deficient mice. Mice lacking both AIM2 and IFNAR2 were protected against the infection. The detrimental effects of type I IFN signaling were due to its ability to induce activation of apoptotic caspases and cell death. These results demonstrate the contrasting effects of type I IFN signaling and AIM2 during F. novicida infection in vivo and indicate a dominant role for type I IFNs in mediating detrimental responses despite the protective AIM2 inflammasome responses.

PROVIDER: S-EPMC6204211 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC5624647 | BioStudies
| S-EPMC6347470 | BioStudies
| S-EPMC4367159 | BioStudies
| S-EPMC6317867 | BioStudies
| S-EPMC4406811 | BioStudies
| E-GEOD-66461 | BioStudies
2015-03-04 | E-GEOD-66461 | ArrayExpress
| S-EPMC2118578 | BioStudies
2010-01-01 | S-EPMC2879132 | BioStudies
| S-EPMC6251914 | BioStudies