Unknown

Dataset Information

0

The Tissue-Engineered Human Psoriatic Skin Substitute: A Valuable In Vitro Model to Identify Genes with Altered Expression in Lesional Psoriasis.


ABSTRACT: Psoriasis is a chronic inflammatory skin disease for which no cure has emerged. Its complex etiology requires the development of an in vitro model representative of the pathology. In this study, we exploited gene profiling analyses on microarray in order to characterize and further optimize the production of a human psoriatic skin model representative of this in vivo skin disease. Various skin substitutes were produced by tissue-engineering using biopsies from normal, healthy donors, or from lesional or non-lesional skin samples from patients with psoriasis, and their gene expression profiles were examined by DNA microarray. We demonstrated that more than 3540 and 1088 genes (two-fold change) were deregulated between healthy/lesional and lesional/non-lesional psoriatic substitutes, respectively. Moreover, several genes related to lipid metabolism, such as PLA2G4E and PLA2G4C, were identified as repressed in the lesional substitutes. In conclusion, gene profiling analyses identified a list of deregulated candidate genes associated with various metabolic pathways that may contribute to the progression of psoriasis.

SUBMITTER: Rioux G 

PROVIDER: S-EPMC6213003 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-09-26 | GSE120464 | GEO
2015-04-01 | E-GEOD-57012 | BioStudies
2019-01-01 | S-EPMC6882360 | BioStudies
2020-01-01 | S-EPMC7033101 | BioStudies
2013-01-01 | S-EPMC3585296 | BioStudies
2021-05-06 | PXD021673 | Pride
2013-01-28 | E-GEOD-34248 | ArrayExpress
2015-04-11 | E-GEOD-67762 | ArrayExpress
2017-01-01 | S-EPMC5741737 | BioStudies
2009-01-01 | S-EPMC2649503 | BioStudies