Squalene emulsions for parenteral vaccine and drug delivery.
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ABSTRACT: Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.
SUBMITTER: Fox CB
PROVIDER: S-EPMC6254918 | BioStudies | 2009-01-01T00:00:00Z
SECONDARY ACCESSION(S): NCT00702221
REPOSITORIES: biostudies
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