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Retrospective estimation of heart and lung doses in pediatric patients treated with spinal irradiation.


ABSTRACT: BACKGROUND AND PURPOSE:The purpose of this study was to investigate whether treatment information from medical records can be used to estimate radiation doses to heart and lungs retrospectively in pediatric patients receiving spinal irradiation with conventional posterior fields. MATERIAL AND METHODS:An algorithm for retrospective dosimetry in children treated with spinal irradiation was developed in a cohort of 21 pediatric patients with available CT-scans and treatment plans. We developed a multivariable linear regression model with explanatory variables identifiable in case note review for retrospective estimation of minimum, maximum, mean and V10%-V80% doses to the heart and lungs. Doses were estimated for both linear accelerator (Linac) and 60Co radiation therapy modalities. RESULTS:Age and spinal field width were identified as statistically significant predictors of heart and lung doses in multivariable analyses (p?

SUBMITTER: Gasic D 

PROVIDER: S-EPMC6261493 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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