Unknown

Dataset Information

0

A new urease inhibitor from Viola betonicifolia.


ABSTRACT: Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.

SUBMITTER: Muhammad N 

PROVIDER: S-EPMC6270924 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC239369 | BioStudies
1000-01-01 | S-EPMC3997575 | BioStudies
2019-01-01 | S-EPMC6494997 | BioStudies
1000-01-01 | S-EPMC196161 | BioStudies
1000-01-01 | S-EPMC4152890 | BioStudies
2017-01-01 | S-EPMC5500380 | BioStudies
1000-01-01 | S-EPMC174160 | BioStudies
2014-01-01 | S-EPMC3918579 | BioStudies
2013-01-01 | S-EPMC3575251 | BioStudies
2017-01-01 | S-EPMC5207512 | BioStudies