Dataset Information


Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.

ABSTRACT: The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2-17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2',4'-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.

PROVIDER: S-EPMC6274457 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC6154579 | BioStudies
2013-01-01 | S-EPMC3639811 | BioStudies
| S-EPMC7730820 | BioStudies
| S-EPMC6495113 | BioStudies
| S-EPMC4131571 | BioStudies
| S-EPMC7653670 | BioStudies
2019-01-01 | S-EPMC6384676 | BioStudies
| S-EPMC8052137 | BioStudies
2018-01-01 | S-EPMC6222840 | BioStudies
| S-EPMC7504814 | BioStudies