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MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.


ABSTRACT: Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.

SUBMITTER: Dluzen DF 

PROVIDER: S-EPMC6309899 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

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