Unknown

Dataset Information

0

Enhancing the Anticancer Efficacy of Immunotherapy through Combination with Histone Modification Inhibitors.


ABSTRACT: In the nucleus of each cell, the DNA is wrapped around histone octamers, forming the so-called "nucleosomal core particles". The histones undergo various modifications that influence chromatin structure and function, including methylation, acetylation, ubiquitination, phosphorylation, and SUMOylation. These modifications, known as epigenetic modifications (defined as heritable molecular determinants of phenotype that are independent of the DNA sequence), result in alterations of gene expression and changes in cell behavior. Recent work has shown that epigenetic drugs targeting histone deacetylation or methylation modulate the immune response and overcome acquired resistance to immunotherapy. A number of combination therapies involving immunotherapy and epigenetic drugs, which target histone deacetylation or methylation, are currently under various clinical/pre-clinical investigations and have shown promising anticancer efficacy. These combination therapies may provide a new strategy for achieving sustained anticancer efficacy and overcoming resistance.

SUBMITTER: Sun W 

PROVIDER: S-EPMC6315613 | BioStudies | 2018-01-01

SECONDARY ACCESSION(S): NCT01684150

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6058186 | BioStudies
2019-01-01 | S-EPMC6348528 | BioStudies
2014-01-01 | S-EPMC4113545 | BioStudies
2009-01-01 | S-EPMC2654015 | BioStudies
1000-01-01 | S-EPMC3026992 | BioStudies
2017-01-01 | S-EPMC5565684 | BioStudies
1000-01-01 | S-EPMC3592566 | BioStudies
2016-01-01 | S-EPMC5033486 | BioStudies
1000-01-01 | S-EPMC4005658 | BioStudies
1000-01-01 | S-EPMC4495356 | BioStudies