Unknown

Dataset Information

0

Alicyclic ?- and ?-Amino Acids: Useful Scaffolds for the Stereocontrolled Access to Amino Acid-Based Carbocyclic Nucleoside Analogs.


ABSTRACT: Stereocontrolled synthesis of some amino acid-based carbocyclic nucleoside analogs containing ring C=C bond has been performed on ?- and ?-lactam basis. Key steps were N-arylation of readily available ?- or ?-lactam-derived amino ester isomers and amino alcohols with 5-amino-4,6-dichloropyrimidine; ring closure of the formed adduct with HC(OMe)? and nucleophilic displacement of chlorine with various N-nucleophiles in the resulting 6-chloropurine moiety.

SUBMITTER: Remete AM 

PROVIDER: S-EPMC6337571 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC6270366 | BioStudies
2003-01-01 | S-EPMC3153471 | BioStudies
2011-01-01 | S-EPMC3499733 | BioStudies
1000-01-01 | S-EPMC6175094 | BioStudies
2016-01-01 | S-EPMC5378675 | BioStudies
1000-01-01 | S-EPMC5954973 | BioStudies
2009-01-01 | S-EPMC2910114 | BioStudies
2009-01-01 | S-EPMC2727169 | BioStudies
2016-01-01 | S-EPMC5053896 | BioStudies
1000-01-01 | S-EPMC5471929 | BioStudies