Unknown

Dataset Information

0

Gut microbiota profiling with differential tolerance against the reduced dietary fibre level in rabbit.


ABSTRACT: Dietary fibre is well acknowledged to be critical in maintaining the gut homeostasis in human and other monogastric animals. As a small monogastric herbivorous animal, rabbit is much sensitive to the reduced intake of dietary fibre and more interestingly shows individual difference in clinical tolerance. In the present study, we fed rabbits with fibre-deficiency diet for two weeks and successfully distinguished the individual tolerances according to clinical signs and gastrointestinal gross lesions. A total of 40 treatments were classified into three groups of the full health (N?=?10), moderate intestinal disorder (N?=?11) and severe intestinal disorder (N?=?19). Together with three controls, 43 individuals were subjected to gut microbiota profiling by 16S rRNA gene sequencing. It was revealed that the Firmicutes/Bacteroidetes ratio steadily decreased from 1.74 in healthy group to 1.03 in severe group. However, the healthy individuals that showed complete tolerance still remained a comparable Firmicutes/Bacteroidetes ratio with controls. Notably, the class Alphaproteobacteria was found to be higher abundance in healthy group than controls and other treatment groups. The results would improve our understanding of the relationship among dietary fibre, gut microbiota and host health.

SUBMITTER: Chen SY 

PROVIDER: S-EPMC6342909 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7160496 | BioStudies
1000-01-01 | S-EPMC4945739 | BioStudies
2015-01-01 | S-EPMC4625062 | BioStudies
2020-01-01 | S-EPMC7028471 | BioStudies
2014-01-01 | S-EPMC4023135 | BioStudies
2018-01-01 | S-EPMC6278000 | BioStudies
2020-01-01 | S-EPMC7589489 | BioStudies
2019-01-01 | S-EPMC6901590 | BioStudies
2017-01-01 | S-EPMC6765500 | BioStudies
2020-01-01 | S-EPMC7424811 | BioStudies