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Is there a reliable size cut-off for splenic involvement in lymphoma? A [18F]FDG-PET controlled study.


ABSTRACT: PURPOSE:Aim of present study was to determine whether the currently recommended 13-cm cranio-caudal diameter cut-off on CT for assessment of splenic involvement in lymphoma offers adequate sensitivity and specificity. MATERIALS AND METHODS:Patients with histologically proven lymphoma who had undergone [18F]FDG-PET/CT before therapy were included. Cranio-caudal diameters of the spleen were measured on the CT component of PET/CT, and ROC analyses with calculation of respective areas under the curve (AUC) were used to determine cut-off values of cranio-caudal measurements with their respective sensitivities and specificities, using [18F]FDG-PET as the reference standard. RESULTS:In 93 patients, we found a sensitivity of 74.1% and a specificity of 47% for the 13-cm splenic diameter cut-off. CONCLUSIONS:Our results show reasonable, though far from perfect sensitivities and specificities for the currently recommend 13-cm splenic diameter cut-off.

SUBMITTER: Berzaczy D 

PROVIDER: S-EPMC6407760 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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