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Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction.


ABSTRACT: To fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP⁻NSHs). The click polymerization completed in merely 4 h to produce the desired MIP⁻NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP⁻NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 μmol•g-1) towards hypericin. The imprinting factors of MIP⁻NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively.

SUBMITTER: Pei Y 

PROVIDER: S-EPMC6418589 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

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