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New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava.


ABSTRACT: A detailed chemical investigation of the South China Sea soft corals Clavularia viridis and Lemnalia flava yielded four new halogenated laurane-type sesquiterpenoids, namely, isobromolaurenisol (1), clalaurenol A (2), ent-laurenisol (3), clalaurenol B (4), and the new aromadendrane-type sesquiterpenoid claaromadendrene (6), together with three known sesquiterpenoids (5, 7, and 8). Their structures were determined by extensive spectroscopic analysis and by comparison with the previously reported analogues. In a bioassay, compounds 1, 2 and 4 exhibited interesting inhibitory activities in vitro against PTP1B and NF-?B.

SUBMITTER: Wu Q 

PROVIDER: S-EPMC6423584 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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