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Survival and glycemic control in patients with coexisting melanoma and diabetes mellitus.


ABSTRACT: Aim:Given the lack of data in the literature, we examined the impact of diabetes mellitus (DM) on melanoma survival and the impact of melanoma on glycemic control. Materials & methods:Patients with melanoma with and without DM were matched 1:1 (2005-2016). Kaplan-Meier analysis was used to estimate overall survival and progression-free survival (PFS). Mixed models compared hemoglobin A1c (HbA1c) and glucose measures over time. Results:Mean HbA1c during the year after cancer diagnosis was 6.7%. The 5-year PFS rate was 89% (95% CI: 81-99%) for patients with DM and 63% (95% CI: 51-79%) for patients without DM (p = 0.02). Conclusion:Melanoma did not adversely impact glycemic control. The DM did not adversely impact survival of patients with melanoma, although increased PFS for melanoma was seen in individuals with DM.

SUBMITTER: Karlin NJ 

PROVIDER: S-EPMC6426167 | BioStudies | 2019-01-01

SECONDARY ACCESSION(S): NCT03026517

REPOSITORIES: biostudies

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