Dataset Information


?-Selective Glycosylation with ?-Glycosyl Sulfonium Ions Prepared via Intramolecular Alkylation.

ABSTRACT: Stereoselective glycosylation remains the main challenge in the chemical synthesis of oligosaccharides. Herein we report a simple method to convert thioglycosides into ?-sulfonium ions via an intramolecular alkylation reaction, leading to highly ?-selective glycosylations for a variety of glycosyl acceptors. The influence of the thioglycoside substituent and the protecting group pattern on the glycosyl donor was investigated and showed a clear correlation with the observed stereoselectivity.

PROVIDER: S-EPMC6454400 | BioStudies |

REPOSITORIES: biostudies

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