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GBA and APOE ?4 associate with sporadic dementia with Lewy bodies in European genome wide association study.


ABSTRACT: Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 720 DLB cases and 6490 controls and included 19 top-associated single-nucleotide polymorphisms in an additional cohort of 108 DLB cases and 75545 controls from Iceland. Overall the study included 828 DLB cases and 82035 controls. Variants in the ASH1L/GBA (Chr1q22) and APOE ?4 (Chr19) loci were associated with DLB surpassing the genome-wide significance threshold (p?

PROVIDER: S-EPMC6504850 | BioStudies |

REPOSITORIES: biostudies

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