Dataset Information


OSCA: a tool for omic-data-based complex trait analysis.

ABSTRACT: The rapid increase of omic data has greatly facilitated the investigation of associations between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts. Here, we propose a mixed-linear-model-based method called MOMENT that tests for association between a DNAm probe and trait with all other distal probes fitted in multiple random-effect components to account for unobserved confounders. We demonstrate by simulations that MOMENT shows a lower false positive rate and more robustness than existing methods. MOMENT has been implemented in a versatile software package called OSCA together with a number of other implementations for omic-data-based analyses.


PROVIDER: S-EPMC6537380 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7518594 | BioStudies
2018-01-01 | S-EPMC6235560 | BioStudies
2015-01-01 | S-EPMC4624379 | BioStudies
2015-01-01 | S-EPMC4324155 | BioStudies
2020-01-01 | S-EPMC7046630 | BioStudies
2019-01-01 | S-EPMC6462396 | BioStudies
2019-01-01 | S-EPMC6737184 | BioStudies
1000-01-01 | S-EPMC6030824 | BioStudies
2020-01-01 | S-EPMC7303201 | BioStudies
2019-01-01 | S-EPMC6986235 | BioStudies