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AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.


ABSTRACT: Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.

PROVIDER: S-EPMC6588460 | BioStudies |

REPOSITORIES: biostudies

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