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Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.

ABSTRACT: PURPOSE:Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS:Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC ?=?10-40?cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y). Myocardial blood flow (MBF) and temporal signal-to-noise (TSNR) were measured. RESULTS:VSASL sensitivity to perfusion decreased with increasing VC . At low VC (<5?cm/s), spurious labeling of myocardium occurs and overestimates MBF. MBF measured with FAIR (1.12?±?0.26?ml/g/min) and VASL (1.26?±?0.27?ml/g/min) at VC of 10?cm/s in Z were comparable (TOST with difference of 0.30?ml/g/min, P?=?0.049). TSNR was 2.8 times larger using FAIR (13.62?±?5.25) than in VSASL (4.87?±?1.58). VSASL was insensitive to perfusion in the Y direction. X and Z performed similarly with TSNR of 4.17?±?2.32 and 3.97?±?0.56, respectively. CONCLUSION:VSASL is a promising alternative to FAIR ASL in the heart and is well suited for scenarios when transit delays are long. Magn Reson Med 80:272-278, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


PROVIDER: S-EPMC6598714 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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