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Iron-Catalyzed Borrowing Hydrogen C-Alkylation of Oxindoles with Alcohols.


ABSTRACT: A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employing a (cyclopentadienone)iron carbonyl complex (2?mol?%) exhibited a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles underwent selective mono-C3-alkylation in good-to-excellent isolated yields (28?examples, 50-92?% yield, 79?% average yield).

SUBMITTER: Dambatta MB 

PROVIDER: S-EPMC6619250 | BioStudies | 2019-01-01

SECONDARY ACCESSION(S): 10.17035/d.2019.0072633299

REPOSITORIES: biostudies

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