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The nasal methylome as a biomarker of asthma and airway inflammation in children.


ABSTRACT: The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9?y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) and lung function. We find multiple differentially methylated CpGs (FDR?

SUBMITTER: Cardenas A 

PROVIDER: S-EPMC6625976 | BioStudies | 2019-01-01

SECONDARY ACCESSION(S): GSE65163

REPOSITORIES: biostudies

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