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DNA methylation and inflammation marker profiles associated with a history of depression.


ABSTRACT: Depression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an inflammatory etiology including many inflammatory-related disorders. At the molecular level, the mechanisms by which depression might promote the onset of these diseases and associated immune-dysfunction are not well understood. In this study we assessed genome-wide patterns of DNA methylation in whole blood-derived DNA obtained from individuals with a self-reported history of depression (n?=?100) and individuals without a history of depression (n?=?100) using the Illumina 450K microarray. Our analysis identified six significant (Šidák corrected P?

SUBMITTER: Crawford B 

PROVIDER: S-EPMC6680088 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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