Unknown

Dataset Information

0

HLA-C levels impact natural killer cell subset distribution and function.


ABSTRACT: Differences in HLA-C expression are inversely correlated with HIV viral load set-point and slower progression to AIDS, linked to enhanced cytotoxic T cell immunity. Yet, beyond T cells, HLA-C serves as a dominant ligand for natural killer (NK) cell killer immunoglobulin-like receptors (KIR). Thus, we speculated that HLA-C expression levels may also impact NK activity, thereby modulating HIV antiviral control. Phenotypic and functional profiling was performed on freshly isolated PBMCs. HLA-C expression was linked to changes in NK subset distribution and licensing, particularly in HLA-C1/C1, KIR2DL3+2DL2-individuals. Moreover, high levels of HLA-C, were associated with reduced frequencies of anergic CD56neg NKs and lower frequencies of KIR2DL1/2/3+ NK cells, pointing to an HLA-C induced influence on the NK cell development in the absence of disease. In HIV infection, several spontaneous controllers, that expressed higher levels of HLA-C demonstrated robust NK-IFN-? secretion in response to target cells, highlighting a second disease induced licensing phenotype. Thus this population study points to a potential role for HLA-C levels both in NK cell education and development.

SUBMITTER: Sips M 

PROVIDER: S-EPMC6684021 | BioStudies | 2016-01-01

SECONDARY ACCESSION(S): 2DS1

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC4197106 | BioStudies
2016-01-01 | S-EPMC4973954 | BioStudies
2018-01-01 | S-EPMC5933048 | BioStudies
2013-01-01 | S-EPMC3689709 | BioStudies
2019-01-01 | S-EPMC6366961 | BioStudies
| S-EPMC4096688 | BioStudies
1000-01-01 | S-EPMC4737201 | BioStudies
2018-01-01 | S-EPMC6023990 | BioStudies
2017-01-01 | S-EPMC5348643 | BioStudies
2019-01-01 | S-EPMC6467198 | BioStudies