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15-Deoxy-?-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-?: Function and Mechanism.

ABSTRACT: 15-Deoxy-?-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-? (PPAR-?) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-? signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-? receptor agonists have been developed, as an endogenous product of PPAR-? receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-?. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.

PROVIDER: S-EPMC6699332 | BioStudies |

REPOSITORIES: biostudies

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