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Evaluating the tumor biology of lung adenocarcinoma: A multimodal analysis.


ABSTRACT: We evaluated the relationships among functional imaging modality such as PET-CT and DW-MRI and lung adenocarcinoma pathologic heterogeneity, extent of invasion depth, and tumor cellularity as a marker of tumor microenvironment.In total, 74 lung adenocarcinomas were prospectively included. All patients underwent 18F-fluorodeoxyglucose (FDG) PET-CT and MRI before curative surgery. Pathology revealed 68 stage I tumors, 3 stage II tumors, and 3 stage IIIA tumors. Comprehensive histologic subtyping was performed for all surgically resected tumors. Maximum standardized uptake value (SUVmax) and ADC values were correlated with pathologic grade, extent of invasion, solid tumor size, and tumor cellularity.Mean solid tumor size (low: 1.7?±?3.0?mm, indeterminate: 13.9?±?14.2?mm, and high grade: 30.3?±?13.5?mm) and SUVmax (low: 1.5?±?0.2, indeterminate: 3.5?±?2.5, and high grade: 15.3?±?0) had a significant relationship with pathologic grade based on 95% confidence intervals (P?=?.01 and P?

SUBMITTER: Kim KH 

PROVIDER: S-EPMC6709045 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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